Enhanced Fluorescence Detection of Interleukin 10 by Means of 1D Photonic Crystals

In the present communication, we report on exploitation of a Bloch surface wave-enhanced fluorescence scheme for detection Interleukin (IL)-10 in protein-rich buffer mimicking biological sample. IL-10 is cytokine known its potent anti-inflammatory and immunosuppressive effects. It considered valuable biomarker prognostic prediction both solid tumors hematological malignancies, recently, distinguishing feature hyperinflammation during severe viral infections. To demonstrate validity technique, transferred all reagents working concentrations used gold-standard such as ELISA, to our assay, with substantial reduction execution time without using any enzymatic amplification recognition. We estimate limit (LoD) terms concentration solution order 110 pg/mL (5.8 pM) 14% accuracy; other terms, presented technique compatible assay range resolution (1.6 commercial ELISA kits. Moreover, LoD successfully matches reported literature COVID-19 patients, making BSW-based sensors viable rapid accurate screening COVID-19-related molecules.